Photoacoustic‐Enabled Self‐Guidance in Magnetic‐Hyperthermia Fe@Fe3O4 Nanoparticles for Theranostics In Vivo

Magnetic nanoparticles have gained much interest for theranostics benefited from their intrinsic integration of imaging and therapeutic abilities. Herein, c(RGDyK) peptide PEGylated Fe@Fe3O4 nanoparticles (RGD‐PEG‐MNPs) are developed for photoacoustic (PA)‐enabled self‐guidance in tumor‐targeting magnetic hyperthermia therapy in vivo. In the αvβ3‐positive U87MG glioblastoma xenograft model, the PA signal of RGD‐PEG‐MNPs reaches its maximum in the tumor at 6 h after intravenous administration. This signal is enhanced by 2.2‐folds compared to that of the preinjection and is also 2.2 times higher than that in the blocking group. It demonstrates the excellent targeting property of RGD‐PEG‐MNPs. With the guidance of the PA, an effective magnetic hyperthermia to tumor is achieved using RGD‐PEG‐MNPs. A single material‐based nanotheranostic agent of c(RGDyK) peptide PEGylated Fe@Fe3O4 nanoparticles is developed for targeting photoacoustic imaging guided magnetic hyperthermia therapy in the αvβ3‐positive U87MG glioblastoma xenograft model.