Icariin exerts inhibitory effects on the growth and metastasis of KYSE70 human esophageal carcinoma cells via PI3K/AKT and STAT3 pathways

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Veröffentlicht in:	Environmental toxicology and pharmacology 2017-09, Vol.54, p.7-13
Hauptverfasser:	Gu, Zhen-Fang, Zhang, Zi-Teng, Wang, Jun-Ye, Xun, Bao-Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Anticancer properties Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antitumor activity Apoptosis Apoptosis - drug effects Cancer Cell cycle Cell Cycle - drug effects Cell growth Cell Line, Tumor Cell migration Cell Proliferation - drug effects Chemotherapy Cytotoxicity Deposition Emergency Esophageal cancer Esophageal carcinoma Esophageal Neoplasms - drug therapy Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophagus Female Flavonoids - pharmacology Flavonoids - therapeutic use Humans Icariin Membrane potential Membrane Potential, Mitochondrial - drug effects Mesenchyme Metastases Metastasis Mice, Nude Mitochondria Molecular chains Natural products Neuroprotection Pharmacology Phosphatidylinositol 3-Kinases - metabolism PI3/AKT Proto-Oncogene Proteins c-akt - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Side effects Signal Transduction - drug effects STAT3 Stat3 protein STAT3 Transcription Factor - metabolism Toxicity Tumor Burden - drug effects
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