In vitro toxicity evaluation of melamine on mouse TM4 Sertoli cells

Highlights • We demonstrated cytotoxicity of melamine (MA) on the TM4 mouse Sertoli cells (TM4 cells). • MA suppressed TM4 cell viability. • MA induced ultrastructural lesions in TM4 cells. • MA induced cell apoptosis in TM4 cells. • MA induced down-regulations of junction-associated protein express...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2017-03, Vol.50, p.111-118
Hauptverfasser:	Chang, Lingling, Wang, Jingyuan, She, Ruiping, Ma, Longhuan, Wu, Qiaoxing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biocompatibility Cadherins Cadherins - metabolism Cell Survival - drug effects Cells Cells, Cultured Cytology Dose-Response Relationship, Drug Down-Regulation Emergency In Vitro Techniques In vivo methods and tests Junction protein Male Melamine Mice Morphology N-Cadherin Occludin - metabolism Proteins Rodents Sertoli cell Sertoli cells Sertoli Cells - cytology Sertoli Cells - drug effects Toxicity Toxicity Tests Triazines - toxicity Vimentin Vimentin - metabolism
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Beschreibung
Zusammenfassung:	Highlights • We demonstrated cytotoxicity of melamine (MA) on the TM4 mouse Sertoli cells (TM4 cells). • MA suppressed TM4 cell viability. • MA induced ultrastructural lesions in TM4 cells. • MA induced cell apoptosis in TM4 cells. • MA induced down-regulations of junction-associated protein expression in TM4 cells.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2017.01.009