11 CMR longitudinal strain analysis in aortic stenosis

IntroductionThere is interest in measures of myocardial health in aortic stenosis (AS) to identify left ventricular (LV) decompensation and optimise timing of surgical intervention. CMR global longitudinal strain (GLS) is increasingly explored. We investigated the relationship of CMR GLS with established markers of AS severity, myocardial fibrosis and clinical outcomes.MethodsCMRs from AS patients (n=159) and healthy controls (n=42) were analysed using commercially available software. LV contours were drawn (long and short-axis cines). Automated analysis calculated 2D and 3D strain. Myocardial fibrosis was assessed using T1-mapping and late-gadolinium enhancement (LGE). Mortality was assessed at 1,466 days (median). Statistical analysis planning was published prior.Results2D-LVGLS correlated with AS severity (Vmax;r=0.24;p=0.0005), ejection fraction (EF, r=−0.33; p