Correlation of Serum Alkaline Phosphatase and Lactate Dehydrogenase with Survival of Stage I-III Breast Cancer Patients

Objective To evaluate the prognostic value of serum alkaline phosphatase (ALP) and serum lactate dehydrogenase (LDH) levels in stage Ⅰ-Ⅲ breast cancer patients before and after treatment. Methods A clinical retrospective analysis was performed with complete data from 476 stage Ⅰ-Ⅲ breast cancer patients who received treatment in the Department of Oncology of Guizhou Cancer Hospital from 2003 to 2012. The median follow-up time was 61 months. Patients’ serum levels of ALP and LDH were detected before and within one week after treatment and then their relationship with recurrence and metastasis rates, PFS and OS were analyzed. Results For stageⅠ-Ⅲ breast cancer patients, OS and PFS in the high ALP level group after treatment were significantly shorter than those in the low ALP level group(P