Expressions of SFRP1 Gene Methylation and SFRP1 Protein in Lung Adenocarcinoma and Related Clinical Significance

Expressions of SFRP1 Gene Methylation and SFRP1 Protein in Lung Adenocarcinoma and Related Clinical Significance

Objective To investigate the expression of SFRP1 gene methylation and SFRP1 protein in lung adenocarcinoma tissues. Methods There were 60 lung adenocarcinoma patients who underwent a completely surgical excision from May 2015 to May 2016. The expression of SFRP1 gene methylation, SFRP1 mRNA and SFRP...

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Veröffentlicht in:Zhongliu fangzhi yanjiu 2017-05, Vol.44 (5), p.320
Hauptverfasser: Li, Xiaojie, Yin, Guilin, Dong, Yongqiang, Zhu, Shuibo, Zhang, Xiaoming, Ji, Tao, Xu, Jiahang
Format: Artikel
Sprache:chi
Schlagworte:
Adenocarcinoma
Clinical significance
Differentiation
DNA methylation
Frizzled-related protein 1
Gene expression
Immunohistochemistry
Lung cancer
Lungs
Lymph nodes
Lymphatic system
Metastases
Metastasis
mRNA
Protein deficiency
Protein expression
Proteins
Surgery
Tissues
Tumors
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Zusammenfassung:Objective To investigate the expression of SFRP1 gene methylation and SFRP1 protein in lung adenocarcinoma tissues. Methods There were 60 lung adenocarcinoma patients who underwent a completely surgical excision from May 2015 to May 2016. The expression of SFRP1 gene methylation, SFRP1 mRNA and SFRP1 protein in lung adenocarcinoma tissues and adjacent tissues were detected respectively by methylation specific PCR, real-time PCR and immunohistochemistry. Results SFRP1 gene methylation rate was higher in tumor tissues than that in adjacent tissues (58.3% vs. 20.0%, P=0.001). The relative expression of SFRP1 mRNA in tumor tissues and adjacent tissues were (0.847±0.297) and (2.019±0.445) (P
ISSN:1000-8578