Synthesis and antiproliferative activity of flavonoid triazolyl glycosides

Sixteen flavonoid triazolyl glycosides were synthesized in good yields Cu(I)-catalyzed azide-alkyne cycloadditions of terminal alkynes of flavonoids with acetylated sugar azides followed by deacetylation with sodium methoxide in anhydrous methanol. The antiproliferative activity of the synthesized c...

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Veröffentlicht in:	Heterocyclic communications 2018-04, Vol.24 (2), p.119-124
Hauptverfasser:	Wang, Gang-qiang, Yan, Li-li, Wang, Qiu-an
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2,3-triazole alkyne Alkynes antiproliferative activity Antiproliferatives azide Biotechnology Cancer Chemical synthesis cycloaddition Flavonoids glycosides
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Zusammenfassung:	Sixteen flavonoid triazolyl glycosides were synthesized in good yields Cu(I)-catalyzed azide-alkyne cycloadditions of terminal alkynes of flavonoids with acetylated sugar azides followed by deacetylation with sodium methoxide in anhydrous methanol. The antiproliferative activity of the synthesized compounds against three human cancer cell lines (Hela, HCC1954 and SK-OV-3) was evaluated. Flavonoids , and flavonoid triazolyl glycosides , , exhibit potent antiproliferative activity against these cancer cell lines.
ISSN:	0793-0283 2191-0197
DOI:	10.1515/hc-2017-0241