Biosynthesis of gold nanoparticles using Prosopis farcta extract and its in vitro toxicity on colon cancer cells
Gold nanoparticles (Au-NPs) were prepared by “green” synthesis through the aqueous extract of Prosopis farcta . The P. farcta is a special herbal, which it can be a suitable candidate in the reduction process of Au 3+ to Au 0 . The structure and morphology of the synthesized Au-NPs were characterize...
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Veröffentlicht in: | Research on chemical intermediates 2018-05, Vol.44 (5), p.3169-3177 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Gold nanoparticles (Au-NPs) were prepared by “green” synthesis through the aqueous extract of
Prosopis farcta
. The
P. farcta
is a special herbal, which it can be a suitable candidate in the reduction process of Au
3+
to Au
0
. The structure and morphology of the synthesized Au-NPs were characterized by UV–visible spectrophotometry, powder X-ray diffraction analysis and high-magnification transmission electron microscopy techniques. The Au-NPs were spherically uniform in shape with particle size of about 25 nm. The cytotoxicity effect of Au-NPs was studied on a colon (HT-29) cancerous cell line via the MTT assay, and the IC
50
of Au-NPs was calculated to be 419.7 µg/mL. The results indicated that the apoptotic effects were increased on cells when the Au-NPs concentration reached 200 µg/mL. The Au-NPs were synthesized easily and with a very low cost and time by
P. farcta
extract for the first time. |
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ISSN: | 0922-6168 1568-5675 |
DOI: | 10.1007/s11164-018-3299-y |