Copper‐Catalyzed Cross‐Coupling of Secondary α‐Haloamides with Terminal Alkynes: Access to Diverse 2,3‐Allenamides

Copper‐Catalyzed Cross‐Coupling of Secondary α‐Haloamides with Terminal Alkynes: Access to Diverse 2,3‐Allenamides

A copper‐catalyzed C(sp)−C(sp3) cross‐coupling of terminal alkynes with readily available secondary α‐haloamides for the efficient synthesis of 2,3‐allenamides is realized. The methodology is characterized by its wide substrate scope, which makes it an important complement to traditional methods for...

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Veröffentlicht in:Advanced synthesis & catalysis 2018-04, Vol.360 (7), p.1397-1401
Hauptverfasser: Lv, Yunhe, Pu, Weiya, Zhu, Xueli, Zhao, Tiantian, Lin, Feifei
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes
Copper
Coupling
cross-coupling
Substrates
trisubstituted allenes
α-haloamides
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Zusammenfassung:A copper‐catalyzed C(sp)−C(sp3) cross‐coupling of terminal alkynes with readily available secondary α‐haloamides for the efficient synthesis of 2,3‐allenamides is realized. The methodology is characterized by its wide substrate scope, which makes it an important complement to traditional methods for synthesizing allenes. A mechanism involving an alkynylcopper species is proposed.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201701556