Copper-mediated Decarboxylative Coupling of Benzamides with Potassium Malonate Monoesters via Directed C–H Cleavage

Copper-mediated Decarboxylative Coupling of Benzamides with Potassium Malonate Monoesters via Directed C–H Cleavage

A copper-mediated decarboxylative coupling of benzamides with potassium malonate monoesters via 8-aminoquinoline-directed C–H cleavage has been developed. This reaction proceeds only by a copper salt to produce the corresponding alkylation products in good yields.

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Veröffentlicht in:Chemistry letters 2018-01, Vol.47 (4), p.450
Hauptverfasser: Takamatsu, Kazutaka, Hirano, Koji, Miura, Masahiro
Format: Artikel
Sprache:eng ; fre ; ger ; jpn
Schlagworte:
Alkylation
Cleavage
Copper
Coupling
Potassium
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Beschreibung
Zusammenfassung:A copper-mediated decarboxylative coupling of benzamides with potassium malonate monoesters via 8-aminoquinoline-directed C–H cleavage has been developed. This reaction proceeds only by a copper salt to produce the corresponding alkylation products in good yields.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.171212