PROTHROMBIN G20210A GENE MUTATION IN PREGNANT FEMALES WITH THROMBOTIC OBSTETRIC COMPLICATIONS

The common hereditary thrombophilic conditions include factor V Leiden mutation, methylene-tetra-hydro-folate reductase mutations, prothrombin gene mutation, plasminogen activator inhibitor-1 (PAI-1) mutation and deficiencies of anticoagulant proteins such as protein C, protein S and anti-thrombin1. Among the hereditary thrombophilic conditions, factor V Leiden mutation and prothrombin gene mutation are more common with a risk of venous thrombosis in terms of odds ratio (OR) of more than 2. A single nucleotide mutation in which guanine is replaced byadenine at position20210 in the 3' untranslated region of the prothrombin gene (denoted as F2 G20210A), is associated with elevated plasma prothrombinlevels and an increased risk of venous thrombosis. Various studies have shown different results about the association of hereditary thrombophilic conditions including F2 G20210 Amutation with complications of pregnancy such as eclampsia/pre-eclampsia, abruptioplacentae (AP), placenta-previa (PP), recurrent abortions, still births, gestational hypertension (GHTN), intrauterine growth retardation (IUGR), intra-uterine death (IUD) and hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome.