Effect of potassium dichromate intake on feed intake and body weight, in female rats, Rattus norvegicus (exposure on three generations)

Material and methods: The experiments included three generations of female rats, each generation holding 28 White Wistar adult female rats, divided in 3 experimental (E) groups, exposed to 25ppmCr - LOAEL(E1), 50 ppm Cr (E2), 75 ppm Cr (E3) and one control (C) group - tap water. Results: It pointed out significant decrease of daily feed mean consumption in the experimental groups comparative to C group, inversely, significantly correlated with the exposure level, in F0, F1 and F2 generations, the mean daily feed intake decreasing with the increase of the number of generations exposed, the lowest being found in the case of F2 generation, followed by F1 generation and F0, the differences being insignificant. Conclusion: The decrease of feed consumption, consecutive to hexavalent chromium intake, led to severe decreases in body weight.