The consequences of lead acetate intake on exposure and integrity biomarkers of reproductive system in female rats at sexual maturity (two generation study)
The aim of the study was the assessment of lead toxic impact on female reproductive system integrity and performances biomarkers. The objectives were: the evaluation of lead levels in ovary, Fallopian tubes and uterus (exposure biomarker) and the structural changes in ovary, Fallopian tubes and uter...
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Veröffentlicht in: | Human & veterinary medicine 2010-06, Vol.2 (1), p.19-24 |
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Sprache: | eng |
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Zusammenfassung: | The aim of the study was the assessment of lead toxic impact on female reproductive system integrity and performances biomarkers. The objectives were: the evaluation of lead levels in ovary, Fallopian tubes and uterus (exposure biomarker) and the structural changes in ovary, Fallopian tubes and uterus (integrity biomarker) at sexual maturity consecutive exposure to lead acetate (50, 100, 150 ppb Pb) in drinking water along two generation (F0, F1). The study pointed out significant increase of lead level in ovaries, Fallopian tubes and uterus comparative to the control group and direct corelation, with different degrees of significance, with the exposure level; severe congestive and degenerative changes in ovary (destruction of parenchymatosa zone, vacuolar epithelial cells, passive vascular congestion, edematous follicle without oocytes, follicle with oocytes) and uterus (necrosis of uterine glands, destruction of uterine lining cells, total detachments of the superficial layers of the epithelia, hypertrophy of the epithelia). |
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ISSN: | 2066-7655 2066-7663 |