Kitcre knock-in mice fail to fate-map cardiac stem cells/reply

Kitcre knock-in mice fail to fate-map cardiac stem cells/reply

In a cell fate-mapping study1 using a cre-knock-in (KI) into the Kit locus, and in two other studies that used a similar genetic approach to track the fate of cardiac stem/progenitor cells (CSCs)2,3, the authors concluded that c-Kitpos (also known as Kitpos) cells only negligibly contributed to the...

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Veröffentlicht in:Nature (London) 2018-03, Vol.555 (7697), p.E1-E18
Hauptverfasser: Vicinanza, Carla, Aquila, Iolanda, Cianflone, Eleonora, Scalise, Mariangela, Marino, Fabiola, Mancuso, Teresa, Fumagalli, Francesca, Giovannone, Emilia Dora, Cristiano, Francesca, Iaccino, Enrico, Marotta, Pina, Torella, Annalaura, Latini, Roberto, Agosti, Valter, Veltri, Pierangelo, Urbanek, Konrad, Isidori, Andrea M, Saur, Dieter, Indolfi, Ciro, Nadal-Ginard, Bernardo, Torella, Daniele, van Berlo, Jop H, Kanisicak, Onur, Maillet, Marjorie, Vagnozzi, Ronald J, Karch, Jason, Lin, Suh-Chin J, Middleton, Ryan C, Marbán, Eduardo, Molkentin, Jeffery D
Format: Artikel
Sprache:eng
Schlagworte:
Bone marrow
Cardiomyocytes
Fate maps
Heart
Heart diseases
Progenitor cells
Proteins
Stem cell transplantation
Stem cells
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Zusammenfassung:In a cell fate-mapping study1 using a cre-knock-in (KI) into the Kit locus, and in two other studies that used a similar genetic approach to track the fate of cardiac stem/progenitor cells (CSCs)2,3, the authors concluded that c-Kitpos (also known as Kitpos) cells only negligibly contributed to the generation of cardiomyocytes. These studies questioned our findings4 that tissue-specific c-Kitpos CSCs are endogenous regenerative agents that are necessary and sufficient for cardiomyocyte regeneration/replenishment after injury.
ISSN:0028-0836
1476-4687
DOI:10.1038/nature25771