ANTIGEN PRESENTATION AND T CELL STIMULATION BY DENDRITIC CELLS

Dendritic cells take up antigens in peripheral tissues, process them into proteolytic peptides, and load these peptides onto major histocompatibility complex (MHC) class I and II molecules. Dendritic cells then migrate to secondary lymphoid organs and become competent to present antigens to T lympho...

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Veröffentlicht in:Annual review of immunology 2002-01, Vol.20 (1), p.621-667
Hauptverfasser: Guermonprez, Pierre, Valladeau, Jenny, Zitvogel, Laurence, Théry, Clotilde, Amigorena, Sebastian
Format: Artikel
Sprache:eng
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Zusammenfassung:Dendritic cells take up antigens in peripheral tissues, process them into proteolytic peptides, and load these peptides onto major histocompatibility complex (MHC) class I and II molecules. Dendritic cells then migrate to secondary lymphoid organs and become competent to present antigens to T lymphocytes, thus initiating antigen-specific immune responses, or immunological tolerance. Antigen presentation in dendritic cells is finely regulated: antigen uptake, intracellular transport and degradation, and the traffic of MHC molecules are different in dendritic cells as compared to other antigen-presenting cells. These specializations account for dendritic cells' unique role in the initiation of immune responses and the induction of tolerance.
ISSN:0732-0582
1545-3278
DOI:10.1146/annurev.immunol.20.100301.064828