ASSOCIATIONS BETWEEN CIRCULATING LEVELS OF PLASMA OF PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 AND VASCULAR OUTCOMES IN AFRICAN AMERICAN DIABETIC PATIENTS

ASSOCIATIONS BETWEEN CIRCULATING LEVELS OF PLASMA OF PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 AND VASCULAR OUTCOMES IN AFRICAN AMERICAN DIABETIC PATIENTS

80% had hypertension, 90% had dyslipidemia and 15% had chronic kidney disease. Multiple linear regression analysis showed that PCSK9 was independently associated with VRI in patients with acceptable glycemic control (β= -0.001, p=0.028, r2= 0.136) after adjustment for other independent variables suc...

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Veröffentlicht in:Journal of the American College of Cardiology 2018-03, Vol.71 (11), p.A1824-A1824
Hauptverfasser: Eluwole, Ayobami, Adedayo, Ajibola M., Tedla, Fasika, Kremer, Arye, Mastrogiovanni, Nicole, Afzal, Mohammed, Rosenberg, Carl, Dreizen, Paul, Rosa, John La, Boutjdir, Mohamed, Banerji, Mary Ann, Brown, Clinton, Salifu, Moro, Lazar, Jason, Bakillah, Ahmed
Format: Artikel
Sprache:eng
Schlagworte:
Cardiology
Diabetes
Diabetes mellitus
Kexin
Metabolic disorders
Proprotein convertases
Subtilisin
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Zusammenfassung:80% had hypertension, 90% had dyslipidemia and 15% had chronic kidney disease. Multiple linear regression analysis showed that PCSK9 was independently associated with VRI in patients with acceptable glycemic control (β= -0.001, p=0.028, r2= 0.136) after adjustment for other independent variables such as age, gender, BMI, dyslipidemia, duration of diabetes, total cholesterol, LDLc, HDLc, creatinine, and triglycerides.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(18)32365-9