STABLE CAVITATION FOR EFFICIENT THROMBOLYSIS IN CORONARY MICRO-CIRCULATION: AN IN-VITRO EXPERIMENTAL STUDY WITH DODECAFLUOROPENTANE ACOUSTIC PHASE-CHANGE NANO-DROPLETS

STABLE CAVITATION FOR EFFICIENT THROMBOLYSIS IN CORONARY MICRO-CIRCULATION: AN IN-VITRO EXPERIMENTAL STUDY WITH DODECAFLUOROPENTANE ACOUSTIC PHASE-CHANGE NANO-DROPLETS

Background For effective elimination of thrombus in coronary micro-circulation after acute myocardial infarction (AMI), stable and sustaining cavitation using ultrasound mediated acoustic phase-change nano-droplets for thrombolysis would be promising. [...]we sought to investigate a novel treatment...

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Veröffentlicht in:Journal of the American College of Cardiology 2018-03, Vol.71 (11), p.A268-A268
Hauptverfasser: Hu, Bo, Jiang, Nan, Zhou, Qing, Cao, Sheng, Deng, Qing, Chen, Jin-Ling, Guo, Rui-Qiang
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Sprache:eng
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Blood clots
Cardiology
Cavitation
Phase transitions
Thrombolysis
Thrombolytic drugs
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container_end_page A268
container_issue 11
container_start_page A268
container_title Journal of the American College of Cardiology
container_volume 71
creator Hu, Bo
Jiang, Nan
Zhou, Qing
Cao, Sheng
Deng, Qing
Chen, Jin-Ling
Guo, Rui-Qiang
description Background For effective elimination of thrombus in coronary micro-circulation after acute myocardial infarction (AMI), stable and sustaining cavitation using ultrasound mediated acoustic phase-change nano-droplets for thrombolysis would be promising. [...]we sought to investigate a novel treatment method of AMI with dodecafluoropentane (DDFP) nano-droplets for rapid and effective thrombolysis in coronary micro-circulation. Methods For PBS blank control (group A), SonoVue microbubbles (group B) and DDFP nano-droplets (group C), the durations for cavitation process were recorded for each group and the thrombolysis efficiency with low intensity focused ultrasound irradiation in an in-vitro vascular system were analyzed with weight loss of thrombus before and after thrombolysis.
doi_str_mv 10.1016/S0735-1097(18)30809-X
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subjects Blood clots
Cardiology
Cavitation
Phase transitions
Thrombolysis
Thrombolytic drugs
title STABLE CAVITATION FOR EFFICIENT THROMBOLYSIS IN CORONARY MICRO-CIRCULATION: AN IN-VITRO EXPERIMENTAL STUDY WITH DODECAFLUOROPENTANE ACOUSTIC PHASE-CHANGE NANO-DROPLETS
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