STABLE CAVITATION FOR EFFICIENT THROMBOLYSIS IN CORONARY MICRO-CIRCULATION: AN IN-VITRO EXPERIMENTAL STUDY WITH DODECAFLUOROPENTANE ACOUSTIC PHASE-CHANGE NANO-DROPLETS

Background For effective elimination of thrombus in coronary micro-circulation after acute myocardial infarction (AMI), stable and sustaining cavitation using ultrasound mediated acoustic phase-change nano-droplets for thrombolysis would be promising. [...]we sought to investigate a novel treatment method of AMI with dodecafluoropentane (DDFP) nano-droplets for rapid and effective thrombolysis in coronary micro-circulation. Methods For PBS blank control (group A), SonoVue microbubbles (group B) and DDFP nano-droplets (group C), the durations for cavitation process were recorded for each group and the thrombolysis efficiency with low intensity focused ultrasound irradiation in an in-vitro vascular system were analyzed with weight loss of thrombus before and after thrombolysis.