Evolutionary recruitment of a flavin-dependent monooxygenase for the detoxification of host plant-acquired pyrrolizidine alkaloids

Evolutionary recruitment of a flavin-dependent monooxygenase for the detoxification of host plant-acquired pyrrolizidine alkaloids

Larvae of Tyria jacobaeae feed solely upon the pyrrolizidine alkaloid-containing plant Senecio jacobaeae. Ingested pyrrolizidine alkaloids (PAs), which are toxic to unspecialized insects and vertebrates, are efficiently N-oxidized in the hemolymph of T. jacobaeae by senecionine N-oxygenase (SNO), a...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2002-04, Vol.99 (9), p.6085
Hauptverfasser: Naumann, Claudia, Hartmann, Thomas, Ober, Dietrich
Format: Artikel
Sprache:eng
Schlagworte:
Butterflies & moths
Evolution
Flowers & plants
Genes
Oxidation
Toxicity
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Zusammenfassung:Larvae of Tyria jacobaeae feed solely upon the pyrrolizidine alkaloid-containing plant Senecio jacobaeae. Ingested pyrrolizidine alkaloids (PAs), which are toxic to unspecialized insects and vertebrates, are efficiently N-oxidized in the hemolymph of T. jacobaeae by senecionine N-oxygenase (SNO), a flavin-dependent monooxygenase (FMO) with a high substrate specificity for PAs.
ISSN:0027-8424
1091-6490