PEDF: Raising Both Hopes and Questions in Controlling Angiogenesis

New work by Bouck and colleagues now gives evidence that a natural protein, pigment epithelium-derived factor (PEDF), is a potent inhibitor of abnormal blood vessel growth in a murine model of ocular neovascularization. This provides compelling evidence that PEDF may be pivotal in controlling both n...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2001-02, Vol.98 (5), p.2122-2124
1. Verfasser: Chader, Gerald J.
Format: Artikel
Sprache:eng
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Zusammenfassung:New work by Bouck and colleagues now gives evidence that a natural protein, pigment epithelium-derived factor (PEDF), is a potent inhibitor of abnormal blood vessel growth in a murine model of ocular neovascularization. This provides compelling evidence that PEDF may be pivotal in controlling both normal and abnormal blood vessel growth.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.061024098