Brønsted Acid‐Catalyzed Tandem Cyclizations of Tryptamine‐Ynamides Yielding 1H‐Pyrrolo[2,3‐d]carbazole Derivatives

Invited for the cover of this issue are the groups of Yongxiang Liu and Maosheng Cheng at Shenyang Pharmaceutical University. The image depicts a tetracyclic indoline, a core scaffold in a series of indole alkaloids. Read the full text of the article at 10.1002/chem.201705189. “…the inherent tendency of C−C bond migration through Wagner–Meerwein rearrangement to generate a tricyclic fused ring system was circumvented by an instantaneous intramolecular nucleophilic trap to indoleninium.” Read more about the story behind the cover in the Cover Profile and about the research itself on page 4026 ff. (DOI: 10.1002/chem.201705189).