A case of non-monotonous influence of pressure on enantioselectivity in supercritical fluid chromatography

A case of non-monotonous influence of pressure on enantioselectivity in supercritical fluid chromatography

non-monotonous dependence of selectivity coefficient on pressure in the enantioseparation of salbutamol sulfate by supercritical fluid chromatography was discovered. When increasing the isothermal pressure of the mobile phase in the interval 100—200 bar at a temperature of 20 °С, the selectivity coe...

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Veröffentlicht in:Russian chemical bulletin 2017-11, Vol.66 (11), p.2190-2193
Hauptverfasser: Pokrovskiy, O. I., Kostenko, M. O., Lunin, V. V.
Format: Artikel
Sprache:eng
Schlagworte:
Brief Communication
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Chromatography
Enantiomers
Inorganic Chemistry
Organic Chemistry
Selectivity
Sorbents
Supercritical fluids
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Zusammenfassung:non-monotonous dependence of selectivity coefficient on pressure in the enantioseparation of salbutamol sulfate by supercritical fluid chromatography was discovered. When increasing the isothermal pressure of the mobile phase in the interval 100—200 bar at a temperature of 20 °С, the selectivity coefficient of separation of salbutamol enantiomers first increased, then decreased, followed by another increase. Such a behavior is atypical and determines the expediency of using pressure to control selectivity in this kind of chromatography.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-017-2001-7