Multiple differences in gene expression in regulatory Valpha24JalphaQ T cells from identical twins discordant for type I diabetes

Multiple differences in gene expression in regulatory Valpha24JalphaQ T cells from identical twins discordant for type I diabetes

Quantitative and qualitative defects in CD1d-restricted T cells have been demonstrated in human and murine autoimmune diseases. To investigate the transcriptional consequences of T cell receptor activation in human Valpha24JalphaQ T cell clones, DNA microarrays were used to quantitate changes in mRN...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2000-06, Vol.97 (13), p.7411
Hauptverfasser: Wilson, S Brian, Kent, Sally C, Horton, Heidi F, Hill, Andrew A
Format: Artikel
Sprache:eng
Schlagworte:
Cells
Diabetes
Genetics
Mutation
Twins
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Zusammenfassung:Quantitative and qualitative defects in CD1d-restricted T cells have been demonstrated in human and murine autoimmune diseases. To investigate the transcriptional consequences of T cell receptor activation in human Valpha24JalphaQ T cell clones, DNA microarrays were used to quantitate changes in mRNA levels after anti-CD3 stimulation of clones derived from identical twins discordant for type 1 diabetes and IL-4 secretion.
ISSN:0027-8424
1091-6490