Differential requirement of the cytoplasmic subregions of gammac chain in T cell development and function

Differential requirement of the cytoplasmic subregions of gammac chain in T cell development and function

The common cytokine receptor gammachain (gammac), a shared component of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15, is critical for the development and function of lymphocytes. The cytoplasmic domain of gammac consists of 85 aa, in which the carboxyl-terminal 48 aa are essential for its int...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2000-09, Vol.97 (19), p.10514
Hauptverfasser: Tsujino, Shiho, Di Santo, James P, Takaoka, Akinori, McKernan, Teresa L
Format: Artikel
Sprache:eng
Schlagworte:
Immunology
Lymphatic system
Membranes
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Zusammenfassung:The common cytokine receptor gammachain (gammac), a shared component of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15, is critical for the development and function of lymphocytes. The cytoplasmic domain of gammac consists of 85 aa, in which the carboxyl-terminal 48 aa are essential for its interaction with and activation of the Janus kinase, Jak3.
ISSN:0027-8424
1091-6490