Some properties of human neuronal alpha7 nicotinic acetylcholine receptors fused to the green fluorescent protein

Some properties of human neuronal alpha7 nicotinic acetylcholine receptors fused to the green fluorescent protein

The functional properties and cellular localization of the human neuronal alpha7 nicotinic acetylcholine (AcCho) receptor (alpha7 AcChorR) and its L248T mutated (mut) form were investigated by expressing them alone or as gene fusions with the enhanced version of the green fluorescent protein (GFP)....

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2002-03, Vol.99 (6), p.3950
Hauptverfasser: Palma, Eleonora, Mileo, Anna M, Martinez-torres, Ataulfo, Eusebi, Fabrizio, Miledi, Ricardo
Format: Artikel
Sprache:eng
Schlagworte:
Cells
Mutation
Neurotransmitters
Proteins
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Zusammenfassung:The functional properties and cellular localization of the human neuronal alpha7 nicotinic acetylcholine (AcCho) receptor (alpha7 AcChorR) and its L248T mutated (mut) form were investigated by expressing them alone or as gene fusions with the enhanced version of the green fluorescent protein (GFP). Xenopus oocytes injected with wild-type, mutalpha7, or the chimeric subunit cDNAs expressed receptors that gated membrane currents when exposed to AcCho.
ISSN:0027-8424
1091-6490