Extension of the Drosophila Lifespan by Overexpression of a Protein Repair Methyltransferase

Atypical protein isoaspartyl residues arise spontaneously during the aging process from the deamidation of protein asparaginyl residues and the isomerization of protein aspartyl residues. These abnormal residues are modified in cells by a strongly conserved protein carboxyl methyltransferase (PCMT)...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-12, Vol.98 (26), p.14814-14818
Hauptverfasser:	Chavous, David A., Jackson, F. Rob, O'Connor, Clare M.
Format:	Artikel
Sprache:	eng
Schlagworte:	actin5C gene Aging Animals Biological Sciences Cellular biology Chromosomes Drosophila Drosophila melanogaster Drosophila melanogaster - embryology Drosophila melanogaster - physiology Eclosion Embryos Genes hsp70 gene In Situ Hybridization Longevity Methyltransferases - metabolism protein carboxyl methyltransferase Proteins Shock heating Transgenes Transponders
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