Closing down on Glyphosate Inhibition-With a New Structure for Drug Discovery

Closing down on Glyphosate Inhibition-With a New Structure for Drug Discovery

New crystallization structure advance the understanding of the interaction of the widely used, broad spectrum herbicide glyphosate with 5-enolpyruvylshikimate-3-phosphate (EPSP) and provide an important opportunity for designing new and unique inhibitors for use as herbicides as well as antibiotic a...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2001-03, Vol.98 (6), p.2944-2946
Hauptverfasser: Alibhai, Murtaza F., Stallings, William C.
Format: Artikel
Sprache:eng
Schlagworte:
3-Phosphoshikimate 1-Carboxyvinyltransferase
Active sites
Alkyl and Aryl Transferases - antagonists & inhibitors
Alkyl and Aryl Transferases - chemistry
Animals
Biochemistry
Chemicals
Commentaries
Crystal structure
Cyclic amino acids
Enzyme Inhibitors - chemistry
Enzymes
Glycine - analogs & derivatives
Glycine - chemistry
Glyphosate
Herbicides
Ligands
Molecules
Pharmacology
Phosphates
Post exposure prophylaxis
Protein Structure, Tertiary
Shikimic Acid - analogs & derivatives
Shikimic Acid - chemistry
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Beschreibung
Zusammenfassung:New crystallization structure advance the understanding of the interaction of the widely used, broad spectrum herbicide glyphosate with 5-enolpyruvylshikimate-3-phosphate (EPSP) and provide an important opportunity for designing new and unique inhibitors for use as herbicides as well as antibiotic and antiparasitic drugs.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.061025898