The effect of pramiracetam in the myelination of the hippocampus in the BALB/c mouse (Mus musculus)

[8] The myelin sheath is a phospholipid layer, formed by oligodendrocytes in the central nervous system and by Schwann cells in the peripheral nervous system, that facilitates synapses and provides structural and biochemical support for the axons of neurons and speeds up neuronal conduction. [10] Myelination has been linked to synaptic plasticity, and it has been suggested that it is more than a developmental process and is related to cognitive functions, which is shown in developed white matter structures in children who have increased cognitive function and motor skills. Since no demyelination was seen, it is possible that the dosage of 200 mg/kg and 600 mg/kg was not sufficient to increase levels of NO in the brain. The hippocampus, a three-layered structure in the temporal lobe, has been linked to long-term memory consolidation and considering that the hippocampus is part of the limbic system along with the amygdala, anterior thalamic nuclei, and the limbic cortex, it can also be associated with learning, memory consolidation, and behavior.