The influence of carrageenan on markers of endogenous intoxication in rats

[9] However, carrageenan was reported to have no effect on virus attachment or penetration into host cells, rather it inhibited synthesis of viral proteins inside the cells. [...]carrageenan has been reported to have anti-HIV activity, but its strong anticoagulant activity is considered to be an adverse effect, preventing its use as therapy for HIV. [...]endogenous intoxication occurs when damaging processes cause accumulation of intermediate and final products of normal metabolism and metabolic disorders in aberrant concentrations in body fluids and tissues. The group includes mainly fragments of protein molecules containing aromatic amino acids, metabolites of urea cycle, purine and pyrimidine, and their derivatives. [...]even the minimal intake of exogenous toxic substances, such as carrageenan in the blood, triggers endogenous intoxication. [27] The main mechanisms which may be involved into bacterial translocation are disruption of immune response, change of the bacterial flora in the small intestine, and increased intestinal permeability. [...]intestinal mucosa is damaged by oxidative stress, which also increases its permeability.