Evidence from in vitro replication that O(6)-methylguanine can adopt multiple conformations

Evidence from in vitro replication that O(6)-methylguanine can adopt multiple conformations

The effect of O6-methylguanine (m6G) on replication has been studied under nonlimiting conditions of unmodified dNTPs and over an extended time period. The results may provide a rationale for why m6G lesions in vivo have been reported to be lethal as well as mutagenic.

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1993-05, Vol.90 (9), p.3983
Hauptverfasser: Dosanjh, M K, Loechler, E L, Singer, B
Format: Artikel
Sprache:eng
Schlagworte:
Bacteria
Biochemistry
Mutation
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Zusammenfassung:The effect of O6-methylguanine (m6G) on replication has been studied under nonlimiting conditions of unmodified dNTPs and over an extended time period. The results may provide a rationale for why m6G lesions in vivo have been reported to be lethal as well as mutagenic.
ISSN:0027-8424
1091-6490