Drosophila lifespan enhancement by exogenous bacteria

We researched the lifespan of Drosophila under axenic conditions compared with customary procedure. The experiments revealed that the presence of bacteria during the first week of adult life can enhance lifespan, despite unchanged food intake. Later in life, the presence of bacteria can reduce lifes...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-08, Vol.101 (35), p.12974-12979
Hauptverfasser:	Brummel, T, Ching, A, Seroude, L, Simon, A.F, Benzer, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Anti-Bacterial Agents - pharmacology Antibiotics Axenic culture Bacteria Biological Sciences Drosophila Drosophila - drug effects Drosophila - genetics Drosophila - microbiology Drosophila - physiology Embryos Food consumption Food intake Food irradiation Genetics Germ-Free Life - physiology Insects Longevity Longevity - drug effects Longevity - physiology Polymerase chain reaction
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Beschreibung
Zusammenfassung:	We researched the lifespan of Drosophila under axenic conditions compared with customary procedure. The experiments revealed that the presence of bacteria during the first week of adult life can enhance lifespan, despite unchanged food intake. Later in life, the presence of bacteria can reduce lifespan. Certain long-lived mutants react in different ways, indicating an interplay between bacteria and longevity-enhancing genes.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.0405207101