Detection of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development

Detection of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development

The role of the T-cell receptor (TCR) beta gene transcriptional enhancer in intrathymic T-cell development was assessed in mouse strains in which the TCR beta enhancer was deleted. The effects of the deletion on lymphoid-cell differentiation, beta gene rearrangement and transcription are described.

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1996-07, Vol.93 (15), p.7877
Hauptverfasser: Bouvier, Gaelle, Watrin, Francoise, Naspetti, Marianne, Verthuy, Christophe
Format: Artikel
Sprache:eng
Schlagworte:
Cells
Genes
Immunity (Disease)
Rodents
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Zusammenfassung:The role of the T-cell receptor (TCR) beta gene transcriptional enhancer in intrathymic T-cell development was assessed in mouse strains in which the TCR beta enhancer was deleted. The effects of the deletion on lymphoid-cell differentiation, beta gene rearrangement and transcription are described.
ISSN:0027-8424
1091-6490