Phenolic composition, antioxidant and pancreatic lipase inhibitory activities of Chinese sumac (Rhus chinensis Mill.) fruits extracted by different solvents and interaction between myricetin‐3‐O‐rhamnoside and quercetin‐3‐O‐rhamnoside

Summary This work was designed to investigate the phenolic composition, antioxidant and pancreatic lipase inhibitory activities of Rhus chinensis Mill. fruits extracted by different solvents, and to illustrate which major phenolic compounds were responsible for lipase inhibition and to evaluate their interactions. Results showed that R. chinensis Mill. fruits were rich in phenolics, which included 13 types identified and quantified by UHPLC‐ESI‐HRMS/MS. Among the identified phenolics, myricetin‐3‐O‐rhamnoside and quercetin‐3‐O‐rhamnoside were the most dominant detected in all extracts. Extracts with 80% methanol, 80% ethanol and 80% acetone exhibited strong antioxidant and pancreatic lipase inhibitory activities in vitro, and these activities were positively correlated with phenolic contents. Myricetin‐3‐O‐rhamnoside and quercetin‐3‐O‐ rhamnoside demonstrated good lipase inhibitory activities in a dose‐dependent manner and synergistically inhibited lipase. This work may provide insights into the potential uses of R. chinensis Mill. fruits in food and nutraceutical industries. Phenolic composition, antioxidant and pancreatic lipase inhibitory activities of Chinese sumac (Rhus chinensis Mill.) fruits extracted by different solvents and interaction between myricetin‐3‐O‐rhamnoside and quercetin‐3‐O‐rhamnoside: Experimental design and main results.