A Drosophila homolog of the tumor suppressor gene adenomatuous polyposis coli down-regulates Beta-catenin but its zygotic expression is not essential for the regulation of Armadillo

Mutations in the adenomatous polyposis coli gene (which encodes a protein called APC) are associated with the formation of intestinal polyps and colon cancers. To facilitate the functional study of APC, Hayashi et al isolated its Drosophila homolog by screening an expression library with an antibody against human APC.