The molecular role of the common gammac subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes

The molecular role of the common gammac subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes

Lai et al define the specific role of the gammac subunit in the interleukin (IL) 2R complex. Results suggest important functional implications for the asymmetric design of many cytokine receptor complexes and the evolutionary design of receptor subfamilies that share common trigger or driver subunit...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1996-01, Vol.93 (1), p.231
Hauptverfasser: Lai, Stephen Y, Xu, Weiduan, Gaffen, Sarah L, Liu, Kathleen D
Format: Artikel
Sprache:eng
Schlagworte:
Immunity (Disease)
Medical research
Proteins
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Zusammenfassung:Lai et al define the specific role of the gammac subunit in the interleukin (IL) 2R complex. Results suggest important functional implications for the asymmetric design of many cytokine receptor complexes and the evolutionary design of receptor subfamilies that share common trigger or driver subunits.
ISSN:0027-8424
1091-6490