Membrane-promoted unfolding of acetycholinesterase: A possible mechanism for insertion into the lipid bilayer

Membrane-promoted unfolding of acetycholinesterase: A possible mechanism for insertion into the lipid bilayer

It is demonstrated that under conditions in which native AcChoEase alone is stable and catalytically active for many hours, DMPC liposomes promote a rapid transition to the partially unfolded MG state.

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1997-04, Vol.94 (7), p.2848
Hauptverfasser: Shin, Irina, Kreimer, David, Silman, Israel, Weiner, Lev
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Lipids
Membranes
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Zusammenfassung:It is demonstrated that under conditions in which native AcChoEase alone is stable and catalytically active for many hours, DMPC liposomes promote a rapid transition to the partially unfolded MG state.
ISSN:0027-8424
1091-6490