Stimulation-dependent IkappaBalpha phosphorylation marks the NF-kappaB inhibitor for degradation via the ubiquitin-proteasome pathway

Stimulation-dependent IkappaBalpha phosphorylation marks the NF-kappaB inhibitor for degradation via the ubiquitin-proteasome pathway

A study showed that the stimulation-dependent pIkappaBalpha is indeed targeted by the proteasome in a specific manner, but must undergo multiubiquitination prior to degradation. This may constitute an integral step of a signal transduction process.

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1995-11, Vol.92 (23), p.10599
Hauptverfasser: Alkalay, Irit, Yaron, Avraham, Hatzubai, Ada, Orian, Amir
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Cellular biology
Proteins
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Zusammenfassung:A study showed that the stimulation-dependent pIkappaBalpha is indeed targeted by the proteasome in a specific manner, but must undergo multiubiquitination prior to degradation. This may constitute an integral step of a signal transduction process.
ISSN:0027-8424
1091-6490