STAT3 activation by cytokines utilizing gp 130 and related transducers involves a secondary modification requiring an H7-sensitive kinase

STAT3 activation by cytokines utilizing gp 130 and related transducers involves a secondary modification requiring an H7-sensitive kinase

A study showed that all cytokines that use gp130 sequentially induce tow distrinct forms of STAT3 in all responding cells examined, with the tow forms apparently differing because of a time-dependent secondary serine/threonine phosphorylation involving an H7-sensitive kinase.

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1995-07, Vol.92 (15), p.6915
Hauptverfasser: Boulton, Teri G, Zhong, Zhong, Wen, Zilong, Darnell, James F
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Proteins
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Zusammenfassung:A study showed that all cytokines that use gp130 sequentially induce tow distrinct forms of STAT3 in all responding cells examined, with the tow forms apparently differing because of a time-dependent secondary serine/threonine phosphorylation involving an H7-sensitive kinase.
ISSN:0027-8424
1091-6490