Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D: Cdk4/6 complexes result in active pRb

Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D: Cdk4/6 complexes result in active pRb

Ezhevesky et al demonstrate that hypo-phosphorylated retinoblatoma protein (pRb) associates with E2F in vivo and is therefore active. It has been concluded that cyclin D: Cdk4/6 complexes hypo-phosphorylate pRb in early G1 allowing continued E2F binding.

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1997-09, Vol.94 (20), p.10699
Hauptverfasser: Ezhevsky, Sergei A, Nagahara, Hikaru, Vocero-Akbani, Adita M, Gius, David R
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Molecular biology
Proteins
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Zusammenfassung:Ezhevesky et al demonstrate that hypo-phosphorylated retinoblatoma protein (pRb) associates with E2F in vivo and is therefore active. It has been concluded that cyclin D: Cdk4/6 complexes hypo-phosphorylate pRb in early G1 allowing continued E2F binding.
ISSN:0027-8424
1091-6490