Identification of Tyr-185 as the site of tyrosine autophosphorylation of recombinant mitogen-activated protein kinase p42(mapk)

Identification of Tyr-185 as the site of tyrosine autophosphorylation of recombinant mitogen-activated protein kinase p42(mapk)

Mass spectrometry and phosphopeptide mapping showed that tyrosine phosphorylation of recombinant p42mapk occurs on Tyr-185, the site of regulatory tyrosine phosphorylation that occurs in mitogen-stimulated mammalian cells.

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1992-07, Vol.89 (13), p.5779
Hauptverfasser: Rossomando, Anthony J, Weber, Michael J, Hunt, Donald F, Sturgill, Thomas W
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Enzymes
Medical research
Proteins
Scientific imaging
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Zusammenfassung:Mass spectrometry and phosphopeptide mapping showed that tyrosine phosphorylation of recombinant p42mapk occurs on Tyr-185, the site of regulatory tyrosine phosphorylation that occurs in mitogen-stimulated mammalian cells.
ISSN:0027-8424
1091-6490