Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulent activity

Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulent activity

Smiley et al demonstrate that the physiologic anticoagulant protein S is interleukin (IL)-4 inducible in primary T cells. Protein S-mediated down-regulation of lymphoid cells procoagulant activity may be one mechanism by which IL-4 antagonizes cell-mediated immunity.

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1997-10, Vol.94 (21), p.11484
Hauptverfasser: Smiley, Stephen T, Boyer, Sarah N, Heeb, Mary J, Griffin, John H, Grusby, Michael J
Format: Artikel
Sprache:eng
Schlagworte:
Immunity (Disease)
Lymphatic system
Medical research
Proteins
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Zusammenfassung:Smiley et al demonstrate that the physiologic anticoagulant protein S is interleukin (IL)-4 inducible in primary T cells. Protein S-mediated down-regulation of lymphoid cells procoagulant activity may be one mechanism by which IL-4 antagonizes cell-mediated immunity.
ISSN:0027-8424
1091-6490