CD8(positive) T cells in psoriatic lesions preferentially use T-cell receptor V(beta)3 and/or V(beta)13.1 genes

CD8(positive) T cells in psoriatic lesions preferentially use T-cell receptor V(beta)3 and/or V(beta)13.1 genes

The persistance of Vbeta3- and/or Vbeta13.1-bearing CD8positive T cells in psoriatic lesions that did not undergo resolution suggests that they are effector cells rather than regulatory cells.

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Bibliographische Detailangaben
Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1994-09, Vol.91 (20), p.9282
Hauptverfasser: Chang, Jennie C C, Smith, Lawrence R, Froning, Karen J, Schwabe, Beverly J
Format: Artikel
Sprache:eng
Schlagworte:
Genes
Immunity (Disease)
Medical disorders
Medical research
Skin
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Beschreibung
Zusammenfassung:The persistance of Vbeta3- and/or Vbeta13.1-bearing CD8positive T cells in psoriatic lesions that did not undergo resolution suggests that they are effector cells rather than regulatory cells.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.91.20.9282