Phosphorylation of the p34 subunit of human single-stranded-DNA-binding protein in cyclin A-activated G(1) extracts is catalyzed by cdk-cyclin A complex and DNA-dependent protein kinase

Phosphorylation of the p34 subunit of human single-stranded-DNA-binding protein in cyclin A-activated G(1) extracts is catalyzed by cdk-cyclin A complex and DNA-dependent protein kinase

A study found that the p34 subunit of the human single-stranded-DNA-binding protein (HSSB) could be hyperphosphorylated by kinase activities present in G1 extract. Results suggest a requirement of the cdk-cyclin A activity for the phosphorylation of p34 by DNA-p350 protein kinase in G1 extract.

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1994-08, Vol.91 (18), p.8343
Hauptverfasser: Pan, Zhen-Qiang, Amin, Anthony A, Gibbs, Emma, Niu, Hongwu, Hurwitz, Jerard
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Deoxyribonucleic acid
DNA
Proteins
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Zusammenfassung:A study found that the p34 subunit of the human single-stranded-DNA-binding protein (HSSB) could be hyperphosphorylated by kinase activities present in G1 extract. Results suggest a requirement of the cdk-cyclin A activity for the phosphorylation of p34 by DNA-p350 protein kinase in G1 extract.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.91.18.8343