Persistent activation of the (zeta) isoform of protein kinase C in the maintenance of long-term potentiation

Persistent activation of the (zeta) isoform of protein kinase C in the maintenance of long-term potentiation

Long-term potentiation in the CA1 region of the hippocampus, a model for memory formation in the brain, is divided into two phases and analyzed. The transition from translocation of protein kinase C to formation of PKM may explain the molecular mechanisms of induction and maintenance of long-term po...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1993-09, Vol.90 (18), p.8342
Hauptverfasser: Osten, Pavel, Valsamis, Helen, Jiang, Xiaolan, Naik, Meghna U
Format: Artikel
Sprache:eng
Schlagworte:
Brain
Enzymes
Medical research
Proteins
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Zusammenfassung:Long-term potentiation in the CA1 region of the hippocampus, a model for memory formation in the brain, is divided into two phases and analyzed. The transition from translocation of protein kinase C to formation of PKM may explain the molecular mechanisms of induction and maintenance of long-term potentiation.
ISSN:0027-8424
1091-6490