Both purified human 1,N(6)-ethenoadenine-binding protein and purified human 3-methyladenine-DNA glycosylase act on 1,N(6)-ethenoadenine and 3-methyladenine

Both purified human 1,N(6)-ethenoadenine-binding protein and purified human 3-methyladenine-DNA glycosylase act on 1,N(6)-ethenoadenine and 3-methyladenine

Cyclic DNA adducts, such as 1,N6-ethenoadenine, are produced by a variety of industrial and environmental chemicals. A study that showed that the properties of two glycosylases (human 1,N6-ethenoadenine-DNA glycosylase and m3A-DNA glycosylase) appear similar is presented.

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1992-10, Vol.89 (20), p.9386
Hauptverfasser: Singer, B, Antoccia, A, Basu, A K, Dosanjh, M K
Format: Artikel
Sprache:eng
Schlagworte:
Cellular biology
Deoxyribonucleic acid
DNA
Proteins
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Zusammenfassung:Cyclic DNA adducts, such as 1,N6-ethenoadenine, are produced by a variety of industrial and environmental chemicals. A study that showed that the properties of two glycosylases (human 1,N6-ethenoadenine-DNA glycosylase and m3A-DNA glycosylase) appear similar is presented.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.89.20.9386