(1)H-((13)C) NMR measurements of (4-(13)C)glutamate turnover in human brain

(1)H-((13)C) NMR measurements of (4-(13)C)glutamate turnover in human brain

Methods such as positron emission tomography have been used to assess regional brain glucose uptake in humans from measurements of the distribution of radioactivity after infusion of isotopically labeled glucose or glucose analogues. Results of studies in which 1H-(13C) nuclear magnetic resonance wa...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1992-10, Vol.89 (20), p.9603
Hauptverfasser: Rothman, D L, Novotny, E J, Shulman, G I, Howseman, A M
Format: Artikel
Sprache:eng
Schlagworte:
Brain
Medical research
NMR
Nuclear magnetic resonance
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Zusammenfassung:Methods such as positron emission tomography have been used to assess regional brain glucose uptake in humans from measurements of the distribution of radioactivity after infusion of isotopically labeled glucose or glucose analogues. Results of studies in which 1H-(13C) nuclear magnetic resonance was used in combination with spectroscopic localization to measure the turnover of (4-13C)glutamate in normal human brain during a (1-13C)glucose infusion are presented.
ISSN:0027-8424
1091-6490