RECA-DEPENDENT RECOVERY OF ARRESTED DNA REPLICATION FORKS
DNA damage encountered during the cellular process of chromosomal replication can disrupt the replication machinery and result in mutagenesis or lethality. The RecA protein of Escherichia coli is essential for survival in this situation: It maintains the integrity of the arrested replication fork an...
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| Veröffentlicht in: | Annual review of genetics 2003-01, Vol.37 (1), p.611-646 |
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| creator | Courcelle, Justin Hanawalt, Philip C |
| description | DNA damage encountered during the cellular process of chromosomal
replication can disrupt the replication machinery and result in mutagenesis or
lethality. The RecA protein of
Escherichia coli
is essential for
survival in this situation: It maintains the integrity of the arrested
replication fork and signals the upregulation of over 40 gene products, of
which most are required to restore the genomic template and to facilitate the
resumption of processive replication. Although RecA was originally discovered
as a gene product that was required to change the genetic information during
sexual cell cycles, over three decades of research have revealed that it is
also the key enzyme required to maintain the genetic information when DNA
damage is encountered during replication in asexual cell cycles. In this
review, we examine the significant experimental approaches that have led to our
current understanding of the RecA-mediated processes that restore replication
following encounters with DNA damage. |
| doi_str_mv | 10.1146/annurev.genet.37.110801.142616 |
| format | Article |
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replication can disrupt the replication machinery and result in mutagenesis or
lethality. The RecA protein of
Escherichia coli
is essential for
survival in this situation: It maintains the integrity of the arrested
replication fork and signals the upregulation of over 40 gene products, of
which most are required to restore the genomic template and to facilitate the
resumption of processive replication. Although RecA was originally discovered
as a gene product that was required to change the genetic information during
sexual cell cycles, over three decades of research have revealed that it is
also the key enzyme required to maintain the genetic information when DNA
damage is encountered during replication in asexual cell cycles. In this
review, we examine the significant experimental approaches that have led to our
current understanding of the RecA-mediated processes that restore replication
following encounters with DNA damage.</description><identifier>ISSN: 0066-4197</identifier><identifier>EISSN: 1545-2948</identifier><identifier>DOI: 10.1146/annurev.genet.37.110801.142616</identifier><identifier>PMID: 14616075</identifier><language>eng</language><publisher>Palo Alto, CA 94303-0139: Annual Reviews</publisher><subject>Cell cycle ; Chromosomes ; Deoxyribonucleic acid ; DNA ; DNA Damage ; DNA repair ; DNA Repair - physiology ; DNA replication ; DNA Replication - physiology ; E coli ; Escherichia coli - genetics ; Escherichia coli - physiology ; Gene Expression Regulation, Bacterial - physiology ; Genomics ; Mutation ; Proteins ; Rec A Recombinases - metabolism ; RecA ; recombination ; repair ; replication</subject><ispartof>Annual review of genetics, 2003-01, Vol.37 (1), p.611-646</ispartof><rights>Copyright © 2003 by Annual Reviews. All rights reserved</rights><rights>COPYRIGHT 2003 Annual Reviews, Inc.</rights><rights>Copyright Annual Reviews, Inc. 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a644t-c0ae40bc93ac57973e12ff5fe9fdb72886935f6213b4eb4ea4a725e74ae81d203</citedby><cites>FETCH-LOGICAL-a644t-c0ae40bc93ac57973e12ff5fe9fdb72886935f6213b4eb4ea4a725e74ae81d203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.genet.37.110801.142616?crawler=true&mimetype=application/pdf$$EPDF$$P50$$Gannualreviews$$H</linktopdf><linktohtml>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.genet.37.110801.142616$$EHTML$$P50$$Gannualreviews$$H</linktohtml><link.rule.ids>70,314,780,784,4182,27924,27925,78254,78255</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14616075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Courcelle, Justin</creatorcontrib><creatorcontrib>Hanawalt, Philip C</creatorcontrib><title>RECA-DEPENDENT RECOVERY OF ARRESTED DNA REPLICATION FORKS</title><title>Annual review of genetics</title><addtitle>Annu Rev Genet</addtitle><description>DNA damage encountered during the cellular process of chromosomal
replication can disrupt the replication machinery and result in mutagenesis or
lethality. The RecA protein of
Escherichia coli
is essential for
survival in this situation: It maintains the integrity of the arrested
replication fork and signals the upregulation of over 40 gene products, of
which most are required to restore the genomic template and to facilitate the
resumption of processive replication. Although RecA was originally discovered
as a gene product that was required to change the genetic information during
sexual cell cycles, over three decades of research have revealed that it is
also the key enzyme required to maintain the genetic information when DNA
damage is encountered during replication in asexual cell cycles. In this
review, we examine the significant experimental approaches that have led to our
current understanding of the RecA-mediated processes that restore replication
following encounters with DNA damage.</description><subject>Cell cycle</subject><subject>Chromosomes</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Damage</subject><subject>DNA repair</subject><subject>DNA Repair - physiology</subject><subject>DNA replication</subject><subject>DNA Replication - physiology</subject><subject>E coli</subject><subject>Escherichia coli - genetics</subject><subject>Escherichia coli - physiology</subject><subject>Gene Expression Regulation, Bacterial - physiology</subject><subject>Genomics</subject><subject>Mutation</subject><subject>Proteins</subject><subject>Rec A Recombinases - metabolism</subject><subject>RecA</subject><subject>recombination</subject><subject>repair</subject><subject>replication</subject><issn>0066-4197</issn><issn>1545-2948</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqVkV1r2zAUhsXYaLOuf2GYXfTOro4sS_LNwCTOVhbi4maDXQnFPioujp36Yx__fnIdGIxSGBIIHT3vqyO9hFwBDQC4uDZNM3b4I7jHBocglK5KFYUAOBMgXpEFRDzyWczVa7KgVAifQyzPydu-f6CUcsmiM3LunEBQGS1InKfLxF-lt-l2lW53nttm39L8u5etvSTP07tduvJW28Qd3G5ulsnuJtt66yz_cveOvLGm7vHytF6Qr-t0t_zsb7JPDtz4RnA--AU1yOm-iENTRDKWIQKzNrIY23IvmVIiDiMrGIR7jm4ablyPKLlBBSWj4QW5mn2PXfs4Yj_oQ9UXWNemwXbsNUiloiiewA__gA_t2DWuN80ogFJcgYP8Gbo3Neqqse3QmWL6zc7UbYO2cuUEgAGTgk588AzvRomHqnhW8HEWFF3b9x1afeyqg-l-a6B6ilCfItRPEepQ6jlCPUfoDN6fnjHuD1j-lZ8yc8ByBiYjUzurCn_2_3_Niy4vq_WxtHr4NYR_AJpFw1Y</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>Courcelle, Justin</creator><creator>Hanawalt, Philip C</creator><general>Annual Reviews</general><general>Annual Reviews, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PADUT</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope></search><sort><creationdate>20030101</creationdate><title>RECA-DEPENDENT RECOVERY OF ARRESTED DNA REPLICATION FORKS</title><author>Courcelle, Justin ; Hanawalt, Philip C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a644t-c0ae40bc93ac57973e12ff5fe9fdb72886935f6213b4eb4ea4a725e74ae81d203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Cell cycle</topic><topic>Chromosomes</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA Damage</topic><topic>DNA repair</topic><topic>DNA Repair - physiology</topic><topic>DNA replication</topic><topic>DNA Replication - physiology</topic><topic>E coli</topic><topic>Escherichia coli - genetics</topic><topic>Escherichia coli - physiology</topic><topic>Gene Expression Regulation, Bacterial - physiology</topic><topic>Genomics</topic><topic>Mutation</topic><topic>Proteins</topic><topic>Rec A Recombinases - metabolism</topic><topic>RecA</topic><topic>recombination</topic><topic>repair</topic><topic>replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Courcelle, Justin</creatorcontrib><creatorcontrib>Hanawalt, Philip C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Research Library China</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><jtitle>Annual review of genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Courcelle, Justin</au><au>Hanawalt, Philip C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RECA-DEPENDENT RECOVERY OF ARRESTED DNA REPLICATION FORKS</atitle><jtitle>Annual review of genetics</jtitle><addtitle>Annu Rev Genet</addtitle><date>2003-01-01</date><risdate>2003</risdate><volume>37</volume><issue>1</issue><spage>611</spage><epage>646</epage><pages>611-646</pages><issn>0066-4197</issn><eissn>1545-2948</eissn><abstract>DNA damage encountered during the cellular process of chromosomal
replication can disrupt the replication machinery and result in mutagenesis or
lethality. The RecA protein of
Escherichia coli
is essential for
survival in this situation: It maintains the integrity of the arrested
replication fork and signals the upregulation of over 40 gene products, of
which most are required to restore the genomic template and to facilitate the
resumption of processive replication. Although RecA was originally discovered
as a gene product that was required to change the genetic information during
sexual cell cycles, over three decades of research have revealed that it is
also the key enzyme required to maintain the genetic information when DNA
damage is encountered during replication in asexual cell cycles. In this
review, we examine the significant experimental approaches that have led to our
current understanding of the RecA-mediated processes that restore replication
following encounters with DNA damage.</abstract><cop>Palo Alto, CA 94303-0139</cop><cop>4139 El Camino Way, P.O. Box 10139</cop><cop>USA</cop><pub>Annual Reviews</pub><pmid>14616075</pmid><doi>10.1146/annurev.genet.37.110801.142616</doi><tpages>36</tpages></addata></record> |
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| ispartof | Annual review of genetics, 2003-01, Vol.37 (1), p.611-646 |
| issn | 0066-4197 1545-2948 |
| language | eng |
| recordid | cdi_proquest_journals_201188481 |
| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | Cell cycle Chromosomes Deoxyribonucleic acid DNA DNA Damage DNA repair DNA Repair - physiology DNA replication DNA Replication - physiology E coli Escherichia coli - genetics Escherichia coli - physiology Gene Expression Regulation, Bacterial - physiology Genomics Mutation Proteins Rec A Recombinases - metabolism RecA recombination repair replication |
| title | RECA-DEPENDENT RECOVERY OF ARRESTED DNA REPLICATION FORKS |
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