Syntheses of 7-dehydrocholesterol peroxides and their improved anticancer activity and selectivity over ergosterol peroxide

7-Dehydrocholesterol peroxide (5α,8α-epidioxycholest-6-ene-3β-ol, CEP) and its acetate and hemisuccinate derivatives were synthesized and isolated for the first time, which exhibit improved anticancer activity and selectivity over ergosterol peroxide (5α,8α-epidioxy-22 E -ergosta-6,22-dien-3β-ol, EE...

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Veröffentlicht in:	New journal of chemistry 2017, Vol.41 (24), p.14843-14846
Hauptverfasser:	Tian, Na-na, Li, Chao, Tian, Na, Zhou, Qian-xiong, Hou, Yuan-jun, Zhang, Bao-wen, Wang, Xue-song
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Cancer Peroxides Selectivity
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Zusammenfassung:	7-Dehydrocholesterol peroxide (5α,8α-epidioxycholest-6-ene-3β-ol, CEP) and its acetate and hemisuccinate derivatives were synthesized and isolated for the first time, which exhibit improved anticancer activity and selectivity over ergosterol peroxide (5α,8α-epidioxy-22 E -ergosta-6,22-dien-3β-ol, EEP), showing potential as new chemotherapeutic agents.
ISSN:	1144-0546 1369-9261
DOI:	10.1039/C7NJ04100D