Supramolecular block copolymers for gene delivery: enhancement of transfection efficiency by charge regulation

A class of cationic supramolecular block copolymers with readily controlled charges has been exploited. Upon post-synthetic structural optimization, this copolymer exhibits comparable biocompatibility, greatly improved pDNA condensation capability and biostability, and further enhanced transfection efficiency in vitro . This work provides valuable insight into the creation of advanced nonviral vectors for gene delivery. A charge controlled supramolecular block copolymer exhibits significantly enhanced gene delivery efficacy in cancer cells without sacrificing the biocompatibility.