A well-defined unimolecular channel facilitates chloride transport

A well-defined unimolecular channel facilitates chloride transport

A unimolecular ion channel was optimized by functionalization with a new type of rigid-rod oligomer. The macrocycle pendant endows chloride selectivity and the fluorescence feature and suitable length of the rod facilitates the visual insertion of channels into the lipid bilayer, resulting in effici...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018-01, Vol.54 (1), p.1249-1252
Hauptverfasser: Chen, Sujun, Zhao, Yongliang, Bao, Chunyan, Zhou, Yaowu, Wang, Chenxi, Lin, Qiuning, Zhu, Linyong
Format: Artikel
Sprache:eng
Schlagworte:
Fluorescence
Ion channels
Ion transport
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Zusammenfassung:A unimolecular ion channel was optimized by functionalization with a new type of rigid-rod oligomer. The macrocycle pendant endows chloride selectivity and the fluorescence feature and suitable length of the rod facilitates the visual insertion of channels into the lipid bilayer, resulting in efficient ion transport with an EC 50 value of 0.36 μM. A well-defined unimolecular channel was optimized for Cl − transport and its fluorescence feature endowed visualization for channel insertion in a membrane.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc09200h